Targeting MDM4 Splicing in Cancers - Institut Curie
Journal Articles Genes Year : 2017

Targeting MDM4 Splicing in Cancers

Abstract

MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. By a mechanism based on alternative splicing, the MDM4 gene generates two mutually exclusive isoforms: MDM4-FL, which encodes the full-length MDM4 protein, and a shorter splice variant called MDM4-S. Previous results suggested that the MDM4-S isoform could be an important driver of tumor development. In this short review, we discuss a recent set of data indicating that MDM4-S is more likely a passenger isoform during tumorigenesis and that targeting MDM4 splicing to prevent MDM4-FL protein expression appears as a promising strategy to reactivate p53 in cancer cells. The benefits and risks associated with this strategy are also discussed.
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Dates and versions

hal-04717205 , version 1 (01-10-2024)

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Boris Bardot, Franck Toledo. Targeting MDM4 Splicing in Cancers. Genes, 2017, 8 (2), pp.82. ⟨10.3390/genes8020082⟩. ⟨hal-04717205⟩
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