ACETYLCHOLINESTERASE Myostatin Muscle DMSXL mice Myotonic dystrophy GSK3␤ CTG repeat contractions Animals Gene editing Glutamate Myotonic dystrophy mouse models Long read sequencing Glucocorticoids Central nervous system Acetylcholinesterase knockout mouse Brain CTG repeat instability Cytoskeleton Duchenne muscular dystrophy Mice CRISPR/Cas9 CONGENITAL MYATHENIC SYNDROME RNA biology Gene therapy Alternative splicing Astrocyte Knockout Thérapie génique Intermediate filament Dystrophin Heart Acute coronary syndrome Cell penetrating peptide CRISPRi Skeletal muscle Desmin Dilated cardiomyopathy Motoneuron Centronuclear myopathy ARN Neuron DM1 Expression CMS Fibrosis Antisense oligonucleotide Cell culture model Dystrophie myotonique Genotype phenotype correlation PacBio Male KNOCKOUT MICE AAV Heart failure Myelin Humans Oligodendrocyte Cell model Oligodendrocytes Aging Hypoxia GABA Trinucleotide repeat expansion Myotonic Dystrophy Endurance training Myotonic dystrophy type 1 CTG repeats Acetylcholinesterase deficiency In vivo Antisense oligonucleotides Therapy Exercice RNA splicing Dynamin 2 Muscular dystrophy Transcriptomics DMPK Transgenic mouse Trinucleotide Repeat Expansion Exercise Astrocytes Diaphragm Quantitative microdialysis Brain dysfunction Myotonic Dystrophy type 1 Gene Therapy Glial cells Maximal force Glucocorticoid-receptor Myotonic Dystrophy Type 1 Mouse model RNA interference Mouse models MBNL Autophagy PCR BIOLOGIE MOLECULAIRE Transgenic mouse model Cardiac muscle Dystrophie Myotonique