%0 Journal Article %T Role of superantigenic strains in the prognosis of community-acquired methicillin-susceptible Staphylococcus aureus bacteraemia %+ Immunité infection vaccination (I2V) %+ Biologie moléculaire et cellulaire des microorganismes (EA3175) %+ Université de Limoges (UNILIM) %+ Centre d'Investigation Clinique de Limoges (CIC1435) %A Desachy, A. %A Lina, G. %A Vignon, P. %A Hashemzadeh, A. %A Denis, François %A Etienne, J. %A François, Bruno %A Ploy, Marie-Cécile %< avec comité de lecture %@ 1198-743X %J Clinical Microbiology and Infection %I Elsevier for the European Society of Clinical Microbiology and Infectious Diseases %V 13 %N 11 %P 1131-1133 %8 2007-11 %D 2007 %R 10.1111/j.1469-0691.2007.01810.x %M 17727671 %Z Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology %Z Life Sciences [q-bio]/Microbiology and Parasitology/Virology %Z Life Sciences [q-bio]/Human health and pathology/Infectious diseasesJournal articles %X Methicillin-susceptible Staphylococcus aureus (MSSA) strains can produce superantigenic toxins that may trigger a massive release of pro-inflammatory cytokines, which are involved in the onset of septic shock. This 1-year prospective pilot study assessed the role of the production of superantigenic toxins in the outcome of immunocompetent patients hospitalised for community-acquired MSSA bacteraemia. Thirty-seven patients were enrolled, of whom 14 died in hospital. Fourteen patients had septic shock, and the mortality rate in this subgroup was 56%. Twenty-seven (73%) isolates produced at least one superantigenic toxin, but this did not influence the rate of occurrence of septic shock or death. %G English %L hal-00404659 %U https://unilim.hal.science/hal-00404659 %~ UNILIM %~ CNRS %~ UNIV-LYON1 %~ UMR-S1092 %~ GEIST %~ UDL %~ UNIV-LYON %~ OMEGAHEALTH