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Article Dans Une Revue PLoS ONE Année : 2012

SNP array analysis reveals novel genomic abnormalities including copy neutral loss of heterozygosity in anaplastic oligodendrogliomas

1 CRICM - Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière
2 CHU Pitié-Salpêtrière [AP-HP]
3 Centre de Référence Maladie Rare "Syndromes neurologiques Paranéoplasiques"
4 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie
5 AltraBio [Lyon]
6 Service d'anatomie pathologique et histologie-cytologie [Rangueil]
7 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
8 Service de Neurochirurgie [CHRU Lille]
9 Service de Neuro-Oncologie [CHRU Nancy]
10 Département Neurologie [CHU Toulouse]
11 Service de Neurochirurgie [CHRU Besançon]
12 Laboratoire d'Histologie et de Pathologie moléculaire des tumeurs
13 Service de neurochirurgie [Bicêtre]
14 Laboratoire d'Anatomie Pathologique [CHU Caen]
15 UPD7 - Université Paris Diderot - Paris 7
16 CRCNA - Centre de Recherche en Cancérologie Nantes-Angers
17 Service de neurochirurgie
18 Service de neurochirurgie [Brest]
19 Service de neurochirurgie [AP-HP Hôpital Lariboisière]
20 INM - Institut des Neurosciences de Montpellier
21 CEPAM - Centre d'Études Préhistoire, Antiquité, Moyen-Age
22 Hôpital Henri Mondor
23 Service de Neurochirurgie
24 CRLCC - CRLCC Eugène Marquis
25 Service de neurochirurgie [CHU Angers]
26 MINT - Micro et Nanomédecines Biomimétiques
27 Service de Neurochirurgie [CHU Saint-Etienne]
28 Service de Neurochirurgie [CHU Amiens]
29 UNICANCER/CJP - Centre Jean Perrin [Clermont-Ferrand]
30 LNC - Lipides - Nutrition - Cancer (U866)
31 UNICANCER/CRLCC-CGFL - Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]
32 CRLCC Paul Strauss - Centre Paul Strauss
33 HCP - Homéostasie Cellulaire et Pathologies
34 Service d'Hématologie biologique [CHU Limoges]
35 UNILIM - Université de Limoges
36 Département de radiothérapie [Gustave Roussy]
37 Stéroides et système nerveux : physiopathologie moléculaire et clinique
Simon de Bernard
  • Fonction : Auteur
Luc Bauchet
Elodie Vauleon
Christine Desenclos
  • Fonction : Auteur
  • PersonId : 1149981
  • IdRef : 148178790
Georges Noel
  • Fonction : Auteur

Résumé

Anaplastic oligodendrogliomas (AOD) are rare glial tumors in adults with relative homogeneous clinical, radiological and histological features at the time of diagnosis but dramatically various clinical courses. Studies have identified several molecular abnormalities with clinical or biological relevance to AOD (e.g. t(1;19)(q10;p10), IDH1, IDH2, CIC and FUBP1 mutations).To better characterize the clinical and biological behavior of this tumor type, the creation of a national multicentric network, named "Prise en charge des OLigodendrogliomes Anaplasiques (POLA)," has been supported by the Institut National du Cancer (InCA). Newly diagnosed and centrally validated AOD patients and their related biological material (tumor and blood samples) were prospectively included in the POLA clinical database and tissue bank, respectively.At the molecular level, we have conducted a high-resolution single nucleotide polymorphism array analysis, which included 83 patients. Despite a careful central pathological review, AOD have been found to exhibit heterogeneous genomic features. A total of 82% of the tumors exhibited a 1p/19q-co-deletion, while 18% harbor a distinct chromosome pattern. Novel focal abnormalities, including homozygously deleted, amplified and disrupted regions, have been identified. Recurring copy neutral losses of heterozygosity (CNLOH) inducing the modulation of gene expression have also been discovered. CNLOH in the CDKN2A locus was associated with protein silencing in 1/3 of the cases. In addition, FUBP1 homozygous deletion was detected in one case suggesting a putative tumor suppressor role of FUBP1 in AOD.Our study showed that the genomic and pathological analyses of AOD are synergistic in detecting relevant clinical and biological subgroups of AOD.
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hal-00911465 , version 1 (13-09-2018)

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Ahmed Idbaih, François Ducray, Caroline Dehais, Célia Courdy, Catherine Carpentier, et al.. SNP array analysis reveals novel genomic abnormalities including copy neutral loss of heterozygosity in anaplastic oligodendrogliomas. PLoS ONE, 2012, 7 (10), pp.e45950. ⟨10.1371/journal.pone.0045950⟩. ⟨hal-00911465⟩
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