<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-00921387</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-17T05:05:03+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap.</title>
            <author role="aut">
              <persName>
                <forename type="first">Devender</forename>
                <surname>Bhalla</surname>
              </persName>
              <idno type="halauthorid">656145-0</idno>
              <affiliation ref="#struct-185397"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Kimly</forename>
                <surname>Chea</surname>
              </persName>
              <email type="md5">3d8a620000df9158f2225e4cf252628c</email>
              <email type="domain">yahoo.com</email>
              <idno type="idhal" notation="numeric">922162</idno>
              <idno type="halauthorid" notation="string">622480-922162</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Chamroeun</forename>
                <surname>Hun</surname>
              </persName>
              <email type="md5">81aa70fb5b0df616e9cf87d45a899568</email>
              <email type="domain">yahoo.com</email>
              <idno type="idhal" notation="numeric">922163</idno>
              <idno type="halauthorid" notation="string">787725-922163</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Mey</forename>
                <surname>Vannareth</surname>
              </persName>
              <idno type="halauthorid">622482-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre</forename>
                <surname>Huc</surname>
              </persName>
              <email type="md5">60a2cf6865a2164891530141fa709248</email>
              <email type="domain">wanadoo.fr</email>
              <idno type="idhal" notation="numeric">922164</idno>
              <idno type="halauthorid" notation="string">363545-922164</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Samleng</forename>
                <surname>Chan</surname>
              </persName>
              <email type="md5">944359f3feeab60fa19dd68b7e626091</email>
              <email type="domain">yahoo.com</email>
              <idno type="idhal" notation="numeric">922165</idno>
              <idno type="halauthorid" notation="string">787726-922165</idno>
              <affiliation ref="#struct-92706"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Robert</forename>
                <surname>Sebbag</surname>
              </persName>
              <idno type="halauthorid">787727-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Daniel</forename>
                <surname>Gérard</surname>
              </persName>
              <email type="md5">dd1c28935bf1e2349123eefca1244ee4</email>
              <email type="domain">sanofi-aventis.com</email>
              <idno type="idhal" notation="numeric">922167</idno>
              <idno type="halauthorid" notation="string">622485-922167</idno>
              <affiliation ref="#struct-92706"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Dumas</surname>
              </persName>
              <email type="md5">40ac560e2108f2b87b4ec13eb611a059</email>
              <email type="domain">yahoo.fr</email>
              <idno type="idhal" notation="numeric">950176</idno>
              <idno type="halauthorid" notation="string">322026-950176</idno>
              <affiliation ref="#struct-185397"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sophal</forename>
                <surname>Oum</surname>
              </persName>
              <email type="md5">27e1ca6486ee82bb44f2824eb723c3b6</email>
              <email type="domain">yahoo.fr</email>
              <idno type="idhal" notation="numeric">950177</idno>
              <idno type="halauthorid" notation="string">622486-950177</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Druet-Cabanac</surname>
              </persName>
              <email type="md5">8f4d87f5d4cae1f364ec02040c234c5d</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="numeric">848546</idno>
              <idno type="halauthorid" notation="string">310470-848546</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5711-3346</idno>
              <idno type="IDREF">https://www.idref.fr/066756723</idno>
              <idno type="VIAF">https://viaf.org/viaf/172176229</idno>
              <idno type="ISNI">http://isni.org/isni/0000000430809636</idno>
              <affiliation ref="#struct-185397"/>
              <affiliation ref="#struct-60050"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Pierre-Marie</forename>
                <surname>Preux</surname>
              </persName>
              <email type="md5">70cf28ac180dfbbe883cb2d56248c5b0</email>
              <email type="domain">unilim.fr</email>
              <idno type="idhal" notation="string">pierre-marie-preux</idno>
              <idno type="idhal" notation="numeric">950093</idno>
              <idno type="halauthorid" notation="string">787385-950093</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2171-2977</idno>
              <idno type="IDREF">https://www.idref.fr/07417357X</idno>
              <idno type="VIAF">https://viaf.org/viaf/193838795</idno>
              <idno type="ISNI">http://isni.org/isni/0000000431147603</idno>
              <affiliation ref="#struct-185397"/>
              <affiliation ref="#struct-60001"/>
              <affiliation ref="#struct-85768"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Elisabeth</forename>
                <surname>Grelier</surname>
              </persName>
              <email type="md5">4fdd7c5ba9a2bf67842ec0a25bdb8817</email>
              <email type="domain">unilim.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2013-12-20 12:18:43</date>
              <date type="whenModified">2025-08-12 17:02:34</date>
              <date type="whenReleased">2013-12-20 12:18:43</date>
              <date type="whenProduced">2012</date>
              <ref type="externalLink" target="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471879"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="133515">
                <persName>
                  <forename>Elisabeth</forename>
                  <surname>Grelier</surname>
                </persName>
                <email type="md5">4fdd7c5ba9a2bf67842ec0a25bdb8817</email>
                <email type="domain">unilim.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-00921387</idno>
            <idno type="halUri">https://unilim.hal.science/hal-00921387</idno>
            <idno type="halBibtex">bhalla:hal-00921387</idno>
            <idno type="halRefHtml">&lt;i&gt;PLoS ONE&lt;/i&gt;, 2012, 7 (10), pp.e46296. &lt;a target="_blank" href="https://dx.doi.org/10.1371/journal.pone.0046296"&gt;&amp;#x27E8;10.1371/journal.pone.0046296&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">PLoS ONE, 2012, 7 (10), pp.e46296. &amp;#x27E8;10.1371/journal.pone.0046296&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNILIM">Université de Limoges</idno>
            <idno type="stamp" n="NET" corresp="UNILIM">Neuroépidémiologie Tropicale</idno>
            <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno>
            <idno type="stamp" n="GEIST" corresp="UNILIM">Génomique, environnement, immunité, thérapeutique</idno>
            <idno type="stamp" n="EPIMACT" corresp="UNILIM">Epidémiologie des Maladies Chroniques en zone tropicale</idno>
            <idno type="stamp" n="OMEGAHEALTH" corresp="UNILIM">OmegaHealth</idno>
            <idno type="stamp" n="LABCIS" corresp="UNILIM">Laboratoire des Agroressources, Biomolécules et Chimie pour l’Innovation en Santé</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Population-based study of epilepsy in Cambodia associated factors, measures of impact, stigma, quality of life, knowledge-attitude-practice, and treatment gap.</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Devender</forename>
                    <surname>Bhalla</surname>
                  </persName>
                  <idno type="halauthorid">656145-0</idno>
                  <affiliation ref="#struct-185397"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Kimly</forename>
                    <surname>Chea</surname>
                  </persName>
                  <email type="md5">3d8a620000df9158f2225e4cf252628c</email>
                  <email type="domain">yahoo.com</email>
                  <idno type="idhal" notation="numeric">922162</idno>
                  <idno type="halauthorid" notation="string">622480-922162</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Chamroeun</forename>
                    <surname>Hun</surname>
                  </persName>
                  <email type="md5">81aa70fb5b0df616e9cf87d45a899568</email>
                  <email type="domain">yahoo.com</email>
                  <idno type="idhal" notation="numeric">922163</idno>
                  <idno type="halauthorid" notation="string">787725-922163</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Mey</forename>
                    <surname>Vannareth</surname>
                  </persName>
                  <idno type="halauthorid">622482-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre</forename>
                    <surname>Huc</surname>
                  </persName>
                  <email type="md5">60a2cf6865a2164891530141fa709248</email>
                  <email type="domain">wanadoo.fr</email>
                  <idno type="idhal" notation="numeric">922164</idno>
                  <idno type="halauthorid" notation="string">363545-922164</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Samleng</forename>
                    <surname>Chan</surname>
                  </persName>
                  <email type="md5">944359f3feeab60fa19dd68b7e626091</email>
                  <email type="domain">yahoo.com</email>
                  <idno type="idhal" notation="numeric">922165</idno>
                  <idno type="halauthorid" notation="string">787726-922165</idno>
                  <affiliation ref="#struct-92706"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Robert</forename>
                    <surname>Sebbag</surname>
                  </persName>
                  <idno type="halauthorid">787727-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Daniel</forename>
                    <surname>Gérard</surname>
                  </persName>
                  <email type="md5">dd1c28935bf1e2349123eefca1244ee4</email>
                  <email type="domain">sanofi-aventis.com</email>
                  <idno type="idhal" notation="numeric">922167</idno>
                  <idno type="halauthorid" notation="string">622485-922167</idno>
                  <affiliation ref="#struct-92706"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Dumas</surname>
                  </persName>
                  <email type="md5">40ac560e2108f2b87b4ec13eb611a059</email>
                  <email type="domain">yahoo.fr</email>
                  <idno type="idhal" notation="numeric">950176</idno>
                  <idno type="halauthorid" notation="string">322026-950176</idno>
                  <affiliation ref="#struct-185397"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sophal</forename>
                    <surname>Oum</surname>
                  </persName>
                  <email type="md5">27e1ca6486ee82bb44f2824eb723c3b6</email>
                  <email type="domain">yahoo.fr</email>
                  <idno type="idhal" notation="numeric">950177</idno>
                  <idno type="halauthorid" notation="string">622486-950177</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Druet-Cabanac</surname>
                  </persName>
                  <email type="md5">8f4d87f5d4cae1f364ec02040c234c5d</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="numeric">848546</idno>
                  <idno type="halauthorid" notation="string">310470-848546</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5711-3346</idno>
                  <idno type="IDREF">https://www.idref.fr/066756723</idno>
                  <idno type="VIAF">https://viaf.org/viaf/172176229</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000430809636</idno>
                  <affiliation ref="#struct-185397"/>
                  <affiliation ref="#struct-60050"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Pierre-Marie</forename>
                    <surname>Preux</surname>
                  </persName>
                  <email type="md5">70cf28ac180dfbbe883cb2d56248c5b0</email>
                  <email type="domain">unilim.fr</email>
                  <idno type="idhal" notation="string">pierre-marie-preux</idno>
                  <idno type="idhal" notation="numeric">950093</idno>
                  <idno type="halauthorid" notation="string">787385-950093</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2171-2977</idno>
                  <idno type="IDREF">https://www.idref.fr/07417357X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/193838795</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000431147603</idno>
                  <affiliation ref="#struct-185397"/>
                  <affiliation ref="#struct-60001"/>
                  <affiliation ref="#struct-85768"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">28700</idno>
                <idno type="issn">1932-6203</idno>
                <idno type="eissn">1932-6203</idno>
                <title level="j">PLoS ONE</title>
                <imprint>
                  <publisher>Public Library of Science</publisher>
                  <biblScope unit="volume">7</biblScope>
                  <biblScope unit="issue">10</biblScope>
                  <biblScope unit="pp">e46296</biblScope>
                  <date type="datePub">2012</date>
                  <date type="dateEpub">2012-10-15</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1371/journal.pone.0046296</idno>
              <idno type="pubmed">23077505</idno>
              <idno type="pubmedcentral">PMC3471879</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="mesh">Cambodia</classCode>
              <classCode scheme="mesh">Epilepsy</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Health Knowledge, Attitudes, Practice</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Quality of Life</classCode>
              <classCode scheme="mesh">Questionnaires</classCode>
              <classCode scheme="mesh">Stereotyping</classCode>
              <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>PURPOSE: Identify epilepsy-associated factors and calculate measures of impact, stigma, quality of life (QOL), knowledge-attitude-practice (KAP) and treatment gap in Prey Veng, Cambodia. METHODS: This first Cambodian population-based case-control study had 96 epileptologist-confirmed epilepsy cases and 192 randomly selected matched healthy controls. Standard questionnaires, which have been used in similar settings, were used for collecting data on various parameters. Univariate and multivariate regression was done to determine odds ratios. Jacoby stigma, 31-item QOL, KAP etc were determined and so were the factors associated with them using STATA software. Treatment gap was measured using direct method. KEY FINDINGS: Multivariate analyses yielded family history of epilepsy, difficult or long delivery, other problems beside seizures (mainly mental retardation, hyperthermia), and eventful pregnancy of the subject's mother as factors associated with epilepsy. There was high frequency of seizure precipitants esp. those related to sleep. Population attributable risk (%) was: family history (15.0), eventful pregnancy of subject's mother (14.5), long/difficult birth (6.5), and other problem beside seizures (20.0). Mean stigma (1.9±1.1, on a scale of 3) was mainly related to treatment efficacy. Mean QOL (5.0±1.4 on a scale of 10) was mainly related to treatment regularity. Cause or risk factor could be determined in 56% of cases. Treatment gap was 65.8%. SIGNIFICANCE: Factors in pre- and perinatal period were found to be most crucial for epilepsy risk in Cambodia which inturn provides major prevention opportunities. A global action plan for treatment, stigma reduction and improvement of QOL should be set-up in this country.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-185397" status="OLD">
          <idno type="IdRef">185648967</idno>
          <idno type="RNSR">201220173E</idno>
          <orgName>Neuroépidémiologie Tropicale</orgName>
          <orgName type="acronym">NET</orgName>
          <date type="start">2012-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr/ient/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
            <relation active="#struct-301268" type="direct"/>
            <relation name="U1094" active="#struct-303623" type="direct"/>
            <relation active="#struct-526218" type="direct"/>
            <relation active="#struct-5928" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-92706" status="VALID">
          <orgName>Sanofi-Aventis R&amp;D</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300501" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-60050" status="VALID">
          <orgName>Service de Santé au Travail [CHU Limoges]</orgName>
          <desc>
            <address>
              <addrLine>Hôpital Le Cluzeau 23, avenue Dominique Larrey 87042 Limoges Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-60001" status="VALID">
          <orgName>Service de l'Information Médicale et de l'Évaluation [CHU Limoges]</orgName>
          <orgName type="acronym">SIME</orgName>
          <desc>
            <address>
              <addrLine>Hôpital Le Cluzeau 23, avenue Dominique Larrey 87042 Limoges Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300906" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-85768" status="VALID">
          <orgName>Laboratoire de Biostatistique et d'Informatique Médicale</orgName>
          <desc>
            <address>
              <addrLine>Faculté de médecine 2 Rue du Docteur Raymond Marcland 87025 LIMOGES Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.unilim.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-5928" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300906" status="VALID">
          <idno type="ROR">https://ror.org/01tc2d264</idno>
          <orgName>CHU Limoges</orgName>
          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301268" status="VALID">
          <orgName>Institut d'Epidémiologie Neurologique et de Neurologie Tropicale</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-526218" status="VALID">
          <idno type="IdRef">224565699</idno>
          <orgName>Institut Génomique, Environnement, Immunité, Santé, Thérapeutique</orgName>
          <orgName type="acronym">GEIST</orgName>
          <date type="start">2018-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.unilim.fr/recherche/laboratoires/geist/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-5928" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-5928" status="VALID">
          <idno type="IdRef">026403315</idno>
          <idno type="ISNI">0000000121654861</idno>
          <idno type="ROR">https://ror.org/02cp04407</idno>
          <orgName>Université de Limoges</orgName>
          <orgName type="acronym">UNILIM</orgName>
          <date type="start">1968-10-01</date>
          <desc>
            <address>
              <addrLine>33 rue François Mitterrand BP23204 87032 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300501" status="VALID">
          <orgName>SANOFI Recherche</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>