%0 Journal Article %T Uncommon Chlorinated Xanthone and Other Antibacterial Compounds from the Lichen Cladonia incrassata %+ Laboratoire de Chimie des Substances Naturelles (LCSN) %+ Service Commun de Résonance Magnétique Nucléaire (RMN) %A Dieu, Amandine %A Millot, Marion %A Champavier, Yves %A Mambu, Lengo, Angèle %A Chaleix, Vincent %A Sol, Vincent %A Gloaguen, Vincent %< avec comité de lecture %@ 0032-0943 %J Planta Medica %I Georg Thieme Verlag %V 80 %P 931-935 %8 2014-07-16 %D 2014 %R 10.1055/s-0034-1382827 %K xanthone %K Cladonia incrassata %K Cladionaceae %K antibacterial %K Staphylococcus aureus %K structure elucidation %Z Chemical Sciences/Medicinal ChemistryJournal articles %X Bioassay-guided fractionation of an extract of the lichen Cladonia incrassata against Staphylococcus aureus led to a novel compound, 1,5-dihydroxy-2,4,6-trichloro-7-methylxanthone (1), along with six known compounds: (−)-usnic acid (2), didymic acid (3), condidymic acid (4), squamatic acid (5), thamnolic acid (6), and prasinic acid (7). Didymic, condidymic, and prasinic acids were isolated for the first time from C. incrassata. Didymic, condidymic, and (−)-usnic acids were active against S. aureus (a minimum inhibitory concentration of 7.5 µg/mL). %G English %L hal-01058414 %U https://unilim.hal.science/hal-01058414 %~ UNILIM %~ CNRS %~ LCSN %~ GEIST %~ PEIRENE %~ OMEGAHEALTH %~ LABCIS