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Article Dans Une Revue Seizure - European Journal of Epilepsy Année : 2016

Overview of accessibility and quality of antiepileptic drugs in Madagascar


PURPOSE: To determine the accessibility of treatment and the quality of antiepileptic drugs (AEDs) in the Haute Matsiatra district of Madagascar. METHODS: Cross-sectional descriptive study and interviews. Samples of 10 units of each available AED were collected, and the active ingredient was quantified by reversed-phase high-performance liquid chromatography (RP-HPLC) with photodiode-array UV detection. The quality of an AED was considered satisfactory if the quantity of active ingredient in each tablet was in the range ±15% of the average value according to the European Pharmacopeia (6th edition, 2008). RESULTS: The area was well served with health infrastructure but rescue facilities were poorly distributed. Available AEDs were all first-generation, and 73% were generic formulations. People with epilepsy (PWE) surveyed consulted traditional healers and most were treated with plants. PWE did not consider themselves sick but believed they were "possessed"; they consulted a doctor only immediately after a seizure, following the advice of traditional healers. The most prescribed AED was phenobarbital, costing between 0.03 and 0.12 US Dollar (US$) per 100mg. The purchase of full treatment was difficult for 77% of PWE and as a result, 39% took nothing. The quality of AEDs were considered unsatisfactory in 2.8% of cases. CONCLUSION: The AEDs collected in Haute Matsiatra were globally of good quality. The main limiting elements were a lack of knowledge among PWE that epilepsy is a disease, and the cost of traditional treatments.
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Dates et versions

hal-01374046 , version 1 (29-09-2016)


  • HAL Id : hal-01374046 , version 1
  • PUBMED : 27552381


Mandy Nizard, Jérémy Jost, Rakotovao Tanamasoandro, Rindra Andriambololona, Mehdi Megherbi, et al.. Overview of accessibility and quality of antiepileptic drugs in Madagascar. Seizure - European Journal of Epilepsy, 2016, 41, pp.134 - 140. ⟨hal-01374046⟩
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