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Article Dans Une Revue Pediatric Emergency Care Année : 2018

Methemoglobinemia Following Monolinuron Ingestion


We describe a case report of a 2-year-old boy presenting to the emergency department with cyanosis and agitation. There was no suggestive history of poisoning but parents reported the presence of an aquarium at the family dinner the night before, with an aquarium cleaner beside it. Physical examination at admission revealed central cyanosis without signs of respiratory distress. Oxygen saturation measured by pulse oximetry (SpO2) was at 80% in room air. Plasma level of methemoglobin was measured at 11.8%. After 6 hours, methemoglobin decreased spontaneously to 5% and pulse oximetry saturation reached 98% in room air. Consciousness, weakness, and behavior were concomitantly improved. Because of rapid and spontaneous improvement, no specific treatment such as methylene blue was administered. A mass spectrometry toxicological analysis was performed in a blood sample taken the day of admission. Screening procedure of pesticides based on liquid chromatography coupled with mass spectrometry identified monolinuron, a phenylurea herbicide.
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Dates et versions

hal-01989765 , version 1 (22-01-2019)



Guillaume Mortamet, Mehdi Oualha, Sylvain Renolleau, Christian Moesch, Jean-Marc Tréluyer. Methemoglobinemia Following Monolinuron Ingestion. Pediatric Emergency Care, 2018, 34 (3), pp.1. ⟨10.1097/PEC.0000000000000745⟩. ⟨hal-01989765⟩
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