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              <p>Background: There is no study available concerning specifically the role of underweight in PAD prevalence. Patients and methods: Individuals ≥ 65 years living in urban and rural areas of two countries in Central Africa (Central African Republic and the Republic of Congo) were invited. Demographic, clinical and biological data were collected, and ankle-brachial index measured. BMI was calculated as weight/height2 and participants were categorized according to the World Health Organization as with underweight (&lt; 18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), and obese (≥ 30 kg/m2). Results: Among the 1815 participants (age 73.0 years, 61.8 % females), the prevalence of underweight was 34.1 %, higher in subjects with PAD than in PAD free subjects (37.1 % vs. 33.5 %, p = 0.0333). The overall prevalence of PAD was 14.3 %. Underweight and obesity were still significantly associated with PAD after adjustment to all potential confounding factors (OR: 2.09, p = 0.0009 respectively OR: 1.90, p = 0.0336) while overweight was no more significantly associated with PAD after multivariate analysis. Conclusions: While obesity is a well-known PAD associated marker, low BMI provides novel independent and incremental information on African subject's susceptibility to present PAD, suggesting a "U-shaped" relationship between BMI and PAD in this population.</p>
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          <orgName>Service de cardiologie [CHU Limoges]</orgName>
          <desc>
            <address>
              <addrLine>Centre Universitaire Dupuytren 2 avenue martin Luther-King 87042 Limoges cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr/</ref>
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          <listRelation>
            <relation active="#struct-300906" type="direct"/>
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        </org>
        <org type="institution" xml:id="struct-327716" status="VALID">
          <orgName>King‘s College London</orgName>
          <desc>
            <address>
              <addrLine>Strand Campus, London WC2R 2LS</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.kcl.ac.uk</ref>
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        </org>
        <org type="laboratory" xml:id="struct-155892" status="VALID">
          <orgName>Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges]</orgName>
          <desc>
            <address>
              <addrLine>CHU Limoges : 2, avenue Martin Luther King 87042 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-limoges.fr/hepato-gastro-enterologie-et-nutrition.html</ref>
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          <listRelation>
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        <org type="laboratory" xml:id="struct-60001" status="VALID">
          <orgName>Service de l'Information Médicale et de l'Évaluation [CHU Limoges]</orgName>
          <orgName type="acronym">SIME</orgName>
          <desc>
            <address>
              <addrLine>Hôpital Le Cluzeau 23, avenue Dominique Larrey 87042 Limoges Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-limoges.fr</ref>
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        <org type="laboratory" xml:id="struct-85768" status="VALID">
          <orgName>Laboratoire de Biostatistique et d'Informatique Médicale</orgName>
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            <address>
              <addrLine>Faculté de médecine 2 Rue du Docteur Raymond Marcland 87025 LIMOGES Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.medecine.unilim.fr/</ref>
          </desc>
          <listRelation>
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        <org type="institution" xml:id="struct-300906" status="VALID">
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          <desc>
            <address>
              <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES</addrLine>
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            <ref type="url">http://www.chu-limoges.fr/</ref>
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        </org>
        <org type="institution" xml:id="struct-301268" status="VALID">
          <orgName>Institut d'Epidémiologie Neurologique et de Neurologie Tropicale</orgName>
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              <country key="FR"/>
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        <org type="institution" xml:id="struct-303623" status="VALID">
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          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-526218" status="VALID">
          <idno type="IdRef">224565699</idno>
          <orgName>Institut Génomique, Environnement, Immunité, Santé, Thérapeutique</orgName>
          <orgName type="acronym">GEIST</orgName>
          <date type="start">2018-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>Université de Limoges - Faculté de Médecine - 2 rue du Dr Marcland 87025 Limoges cedex</addrLine>
              <country key="FR"/>
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            <ref type="url">https://www.unilim.fr/recherche/laboratoires/geist/</ref>
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        <org type="institution" xml:id="struct-5928" status="VALID">
          <idno type="IdRef">026403315</idno>
          <idno type="ISNI">0000000121654861</idno>
          <idno type="ROR">https://ror.org/02cp04407</idno>
          <orgName>Université de Limoges</orgName>
          <orgName type="acronym">UNILIM</orgName>
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          <desc>
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              <addrLine>33 rue François Mitterrand BP23204 87032 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.unilim.fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-571220" status="VALID">
          <orgName>Centre Hospitalier Universitaire Dupuytren 1 et 2</orgName>
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          <desc>
            <address>
              <addrLine>2 Avenue Martin Luther King, 87000 Limoges et 16 Rue Bernard Descottes, 87042 Limoges</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-limoges.fr/</ref>
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          <listRelation>
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  </text>
</TEI>