%0 Journal Article %T Liver elastometry and alcohol withdrawal: Median-term follow-up in a psychiatric unit %+ Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges] %+ Pôle Universitaire d’Addictologie en Limousin %+ Neuroépidémiologie Tropicale (NET) %+ CH Esquirol [Limoges] (CH Esquirol) %A Carrier, Paul %A Girard, Murielle %A Debette-Gratien, Marilyne %A Ouedraogo, Natacha %A Loustaud-Ratti, Véronique %A Nubukpo, Philippe %< avec comité de lecture %@ 0741-8329 %J Alcohol %I Elsevier Masson %V 89 %P 49-56 %8 2020-12 %D 2020 %R 10.1016/j.alcohol.2020.07.007 %K Motivation %K Alcohol withdrawal %K Liver fibrosis %K Alcohol consumption %K Liver stiffness %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X The measurement of liver stiffness (LS) shows promise as a follow-up tool after alcohol withdrawal, but it has mainly been studied in the early phase or in patients with severe liver disease. A 6-month ancillary study of a specific psychiatric cohort of alcoholic patients without known liver disease followed after withdrawal was conducted (Clinical Trial NCT01491347). Clinical and biological data and LS values were collected every 2 months. A total of 129 patients were included in the study; 93 had an LS assessment within the first 7 days, and 37 had all four LS measurements. Only seven (7.5%) patients had an initial LS > 12.1 kPa, the threshold used to define severe fibrosis. Abstinence was not associated with changes inLS at the various median-term follow-up periods. However, LS of abstinent subjects decreased significantly relative to that of non-abstinent subjects between M0 and M2. CAP™ values were not associated with abstinence. The systematic median-term follow-up of withdrawn patients does not appear to be contributory. However, LS could help to detect relapse in the first 2 months after withdrawal for subjects treated in a psychiatric hospital for dependence. It thus could serve as a motivation tool. Prospective studies with various and higher baseline LS values are warranted for simultaneous longitudinal assessment, including for very short- and long-term LS after withdrawal. %G English %2 https://unilim.hal.science/hal-03434259/document %2 https://unilim.hal.science/hal-03434259/file/S0741832920302512.pdf %L hal-03434259 %U https://unilim.hal.science/hal-03434259 %~ INSERM %~ UNILIM %~ NET %~ SANTE_PUB_INSERM %~ GEIST %~ ELSEVIER %~ EPIMACT %~ OMEGAHEALTH %~ LABCIS