%0 Journal Article %T Chronic kidney disease and the short-term risk of mortality and amputation in patients hospitalized for peripheral artery disease %+ Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges] %+ Neuroépidémiologie Tropicale (NET) %+ Service de Cardiologie [CHU de Dijon] %+ Service de Médecine Vasculaire [CHU Toulouse] %+ Service des Maladies Cardiaques et Vasculaires [CHU Bordeaux] %A Lacroix, Philippe %A Aboyans, Victor %A Desormais, Ileana %A Kowalsky, Thierry %A Cambou, Jean Pierre %A Constans, Joel %A Bura Rivière, Alessandra %< avec comité de lecture %@ 0741-5214 %J Journal of Vascular Surgery %I Elsevier %V 58 %N 4 %P 966-971 %8 2013-10 %D 2013 %R 10.1016/j.jvs.2013.04.007 %Z Life Sciences [q-bio]/Santé publique et épidémiologieJournal articles %X Objective: The aim of the present study was to determine the prevalence of chronic kidney disease (CKD) and its prognostic value in patients hospitalized for lower extremity peripheral artery disease (PAD).Methods: Data from the COhorte des Patients ARTériopathes registry, a prospective multicenter, observational study of consecutive patients hospitalized for PAD in academic hospitals of southwestern France, were analyzed. All the subjects were in Rutherford grade ≥ 3, and 55.6% were in grade ≥ 5-6. Associations between CKD and 1-year mortality, as well as amputation rates, were evaluated by Cox analysis. Kaplan-Meier survival curves were analyzed according to estimated glomerular filtration rate (eGFR).Results: From May 2004 to January 2009, we enrolled 1010 patients. They were classified into four groups according to the eGFR: 21.7% were in group 1 (≥ 90 mL/min per 1.73 m(2)), 34% in group 2 (60-89 mL/min per 1.73 m(2)), 32.2% in group 3 (30-59 mL/min per 1.73 m(2)), and 12.1% in group 4 (<30 mL/min per 1.73 m(2) including dialysis). All-cause mortality was 25.1% at 1 year. The rate of major amputation was 26.3%. Mortality rates were, respectively, at 16%, 18%, 31.7%, and 44.3% (P < .0001) in groups 1 to 4. The major amputation rates were at 23.7%, 21.5%, 28%, and 40.2% (P = .0006), respectively. The presence of severe CKD (group 4) was associated with all-cause mortality (hazard ratio, 1.84; 95% confidence interval, 1.02-3.32; P = .044). In contrast, the risk of amputation was not associated with CKD after adjustments to risk factors.Conclusions: The prevalence of CKD in patients hospitalized for PAD is high. CKD is an independent predictor of 1-year mortality, but is not an independent predictor of limb amputation. %G English %L hal-03593020 %U https://unilim.hal.science/hal-03593020 %~ UNILIM %~ NET %~ SANTE_PUB_INSERM %~ GEIST %~ EPIMACT %~ OMEGAHEALTH %~ LABCIS