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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2006

Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT.

Vincent Sol
Y.M. Huang
  • Fonction : Auteur

Résumé

Syntheses of new glycosylated neutral and cationic porphyrin dimers linked at the meso-position via a flexible hydrocarbon chain are described. A detailed 1H and 13C NMR study allows their complete structural elucidation. The UV-visible, fluorescence and MALDI mass spectra are also presented. Photocytotoxicities of these compounds against K562 leukaemia cell line are compared to those of Photofrin II.

Domaines

Chimie organique

Dates et versions

hal-00684103 , version 1 (30-03-2012)

Identifiants

Citer

Vincent Sol, Vincent Chaleix, Yves Champavier, Robert Granet, Y.M. Huang, et al.. Glycosyl bis-porphyrin conjugates: synthesis and potential application in PDT.. Bioorganic and Medicinal Chemistry, 2006, 14 (23), pp.7745-7760. ⟨10.1016/j.bmc.2006.08.004⟩. ⟨hal-00684103⟩
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