Solvent-controlled regioselective protection of 5'-O-protected thymidine. - Université de Limoges Accéder directement au contenu
Article Dans Une Revue Carbohydrate Research Année : 2008

Solvent-controlled regioselective protection of 5'-O-protected thymidine.

Résumé

This paper describes an efficient procedure for selective 3'-O- or 3-N-protection of 5'-O-tert-butyldimethylsilylthymidine, depending on the use of aprotic polar solvents with low or high dielectric constant, respectively. These syntheses were activated by either ultrasound or microwaves. Several alkyl bromides offer a convenient route to prepare 3'-O- or 3-N-protected and functionalized thymidine derivatives.

Dates et versions

hal-00686437 , version 1 (10-04-2012)

Identifiants

Citer

Karine Teste, Ludovic Colombeau, Amel Hadj-Bouazza, Rachida Zerrouki, Romain Lucas, et al.. Solvent-controlled regioselective protection of 5'-O-protected thymidine.. Carbohydrate Research, 2008, 343 (9), pp.1490-5. ⟨10.1016/j.carres.2008.04.026⟩. ⟨hal-00686437⟩
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