A rapid efficient microwave-assisted synthesis of a 3',5'-pentathymidine by copper(I)-catalyzed [3+2] cycloaddition.
Résumé
Starting from 5?-O-tosylthymidine, sequential azidation and Cu-catalyzed [3+2] azide?alkyne 1,3-dipolar cycloaddition led to the formation of a 3?,5?-pentathymidine in high yield. The whole process needed only work-up/precipitation steps and was completed within just 18min, thanks to microwave activation.