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Article Dans Une Revue European Journal of Clinical Pharmacology Année : 2008

Dose-response effect of serum butyrylcholinesterase activity after clinical doses of pancuronium.

C. Motamed
  • Fonction : Auteur
P. Fanen
  • Fonction : Auteur
K. Kirov
  • Fonction : Auteur
P. Duvaldestin
  • Fonction : Auteur

Résumé

INTRODUCTION: Low-dose pancuronium is known to affect serum cholinesterase activity (BChE); however, the dose-response effect of clinical doses of pancuronium on BChE has not been investigated. METHODS: Thirteen ASA I-II patients scheduled for elective surgery requiring muscle relaxation were enrolled in this study. All patients had normal BChE before surgery. Incremental doses of pancuronium (10, 20, 50, and 100 microg/kg) were injected in accordance with surgical needs every 45 min. BChE was measured 3 min after injection by an automatic colorimetric method. RESULTS: BChE decreased significantly in all except one patient in comparison to the baseline (P < 0.05). However all values remained within normal clinical range. A dose of 100 microg/kg yielded significant decrease in comparison to 10 microg/kg but not to other dosages. Linear regression was not significant for the dose-response relationship (P = 0.05). CONCLUSION: After clinical incremental doses of pancuronium, BChE remained within clinical range.

Dates et versions

hal-00738010 , version 1 (03-10-2012)

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Citer

C. Motamed, P. Fanen, P. Feiss, K. Kirov, P. Duvaldestin. Dose-response effect of serum butyrylcholinesterase activity after clinical doses of pancuronium.. European Journal of Clinical Pharmacology, 2008, 64 (11), pp.1043-5. ⟨10.1007/s00228-008-0548-9⟩. ⟨hal-00738010⟩
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