High levels of an endothelial dysfunction marker (sVCAM-1) are associated with injurious and recurrent falls and mortality over a 5-year interval in an older population - Université de Limoges Accéder directement au contenu
Article Dans Une Revue Experimental Gerontology Année : 2018

High levels of an endothelial dysfunction marker (sVCAM-1) are associated with injurious and recurrent falls and mortality over a 5-year interval in an older population

Gregory Wellenius
  • Fonction : Auteur
Sophie Boyer
  • Fonction : Auteur
Thomas Travison
  • Fonction : Auteur
Daniel Habtemariam
  • Fonction : Auteur
Ikechukwu Iloputaife
  • Fonction : Auteur
Farzaneh Sorond
  • Fonction : Auteur
Lewis Lipsitz
  • Fonction : Auteur

Résumé

We investigated the association between elevated plasma concentrations of circulating soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and injurious falls and mortality over a 5-year period. We studied the prospective relationship between levels of circulating adhesion molecules and falls in 680 community-dwelling participants in the MOBILIZE Boston Study. The mean sVCAM-1 (±SD) concentration was 1192 ± 428 ng/mL. Over 5-years of follow-up, 10.2% of participants died. The baseline sVCAM-1 (±SD) concentration was 1434 ± 511 ng/mL in those who died vs. 1162 ± 402 ng/mL in those who survived (P < 0.0001). sVCAM-1 level was associated with recurrent falls (P < 0.01); compared to the lowest quintile, the highest quintile of sVCAM-1 was associated with increased risk of injurious falls [multivariable adjusted Incidence Rate Ratio = 1.9, 95% CI (1.2-2.9), P = 0.009]. On survival analysis, the highest sVCAM-1 quintile was associated with the greatest mortality over 5 years (log-rank test, P < 0.0001). The adjusted hazard ratio was 2.4 [95% CI (2.1-2.7), P = 0.002]. High sVCAM-1 blood concentration was strongly associated with recurrent falls, injurious falls, and mortality in older adults.

Dates et versions

hal-01887214 , version 1 (03-10-2018)

Identifiants

Citer

Achille Tchalla, Gregory Wellenius, Sophie Boyer, Thomas Travison, Daniel Habtemariam, et al.. High levels of an endothelial dysfunction marker (sVCAM-1) are associated with injurious and recurrent falls and mortality over a 5-year interval in an older population. Experimental Gerontology, 2018, 106, pp.1 - 7. ⟨10.1016/j.exger.2018.02.020⟩. ⟨hal-01887214⟩
17 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More