Staging amyotrophic lateral sclerosis: A new focus on progression - Université de Limoges Accéder directement au contenu
Article Dans Une Revue Revue Neurologique Année : 2018

Staging amyotrophic lateral sclerosis: A new focus on progression


Amyotrophic lateral sclerosis (ALS) is a heterogenous motoneuronal neurodegenerative condition with a panel of phenotypes exhibiting different clinical patterns. Two compounds are currently available for the treatment of ALS but the majority of trials have failed to show a positive effect on prognosis. One of the explanations which could be put forward involves the way efficacy is evaluated: clinicians agree that the ALSFRS-revised scale used in all trials does not fit with highlighting a positive effect. So, the development and validation of new tools allowing a reliable assessment of ALS has become a key issue in clinical research. Over the last three years, two functional scales (the King's College and MiToS staging systems) have been proposed. These scales rely on two different approaches to ALS: an anatomical and prognostic concept, and loss of autonomy. Both scales propose five stages. We will discuss below the contribution of these two scales to clinical evaluation and the questions which remain to be resolved in the future.
Fichier non déposé

Dates et versions

hal-02025153 , version 1 (19-02-2019)


  • HAL Id : hal-02025153 , version 1


P. Corcia, S. Beltran, Géraldine Lautrette, S. Bakkouche, Philippe Couratier. Staging amyotrophic lateral sclerosis: A new focus on progression. Revue Neurologique, 2018. ⟨hal-02025153⟩
30 Consultations
0 Téléchargements


Gmail Facebook X LinkedIn More