Article Dans Une Revue Alzheimer's Research and Therapy Année : 2020

Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study

1 Leipzig University / Universität Leipzig
2 Trinity College Dublin
3 Faculty of Medicine [Cologne]
4 DZNE - German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen
5 Universitas Katolik Indonesia Atma Jaya
6 CAM - University of Cambridge [Cambridge, UK]
7 Newcastle University [Newcastle]
8 Albert Einstein College of Medicine [New York]
9 NET - Neuroépidémiologie Tropicale
10 SIME - Service de l'Information Médicale et de l'Évaluation [CHU Limoges]
11 Laboratoire de Biostatistique et d'Informatique Médicale
12 Hôpital de l'Amitié [Bangui]
13 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
14 INM - Institut des Neurosciences de Montpellier
15 The University of Edinburgh
16 Golgi Cenci Foundation
17 SNUBH - Seoul National University Bundang Hospital
18 SNU - Seoul National University [Seoul]
19 Seoul National University Hospital
20 UKM - Universiti Kebangsaan Malaysia
21 USM - Universiti Sains Malaysia
22 MUMC - Maastricht University Medical Centre
23 University of Pittsburgh School of Medicine
24 NeuRA - Neuroscience Research Australia
25 UNSW - University of New South Wales [Sydney]
26 ANU - Australian National University
27 Kyushu University
28 FIT - Fukuoka Institute of Technology
29 Yong Loo Lin School of Medicine [Singapore]
30 Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney
31 CIBER-SAM - Centro de Investigación Biomédica en Red Salud Mental [Madrid]
32 IIS Aragon - Aragón Health Research Institute - Instituto de Investigacion Sanitaria Aragon
33 Universidad de Zaragoza = University of Zaragoza [Saragossa University] = Université de Saragosse
Blossom Stephan
Mindy Katz
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Antonio Guaita
Nicolas Cherbuin
Sanmei Chen
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Résumé

Background: Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods: We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. Results: The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. Conclusions: SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.

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hal-03105760 , version 1 (16-02-2024)

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Susanne Röhr, Alexander Pabst, Steffi Riedel-Heller, Frank Jessen, Yuda Turana, et al.. Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study. Alzheimer's Research and Therapy, 2020, 12 (1), pp.167. ⟨10.1186/s13195-020-00734-y⟩. ⟨hal-03105760⟩
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