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Article Dans Une Revue Journal of Fungi Année : 2022

Access to Anti-Biofilm Compounds from Endolichenic Fungi Using a Bioguided Networking Screening

Seinde Toure
  • Fonction : Auteur
Marion Millot
  • Fonction : Auteur
Zineb Khaldi
  • Fonction : Auteur
Valentin Pichon
  • Fonction : Auteur
Christine Imbert
Lengo Mambu

Résumé

Endolichenic microorganisms represent a new source of bioactive natural compounds. Lichens, resulting from a symbiotic association between algae or cyanobacteria and fungi, constitute an original ecological niche for these microorganisms. Endolichenic fungi inhabiting inside the lichen thallus have been isolated and characterized. By cultivation on three different culture media, endolichenic fungi gave rise to a wide diversity of bioactive metabolites. A total of 38 extracts were screened for their anti-maturation effect on Candida albicans biofilms. The 10 most active ones, inducing at least 50% inhibition, were tested against 24 h preformed biofilms of C. albicans, using a reference strain and clinical isolates. The global molecular network was associated to bioactivity data in order to identify and priorize active natural product families. The MS-targeted isolation led to the identification of new oxygenated fatty acid in Preussia persica endowed with an interesting anti-biofilm activity against C. albicans yeasts.
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Dates et versions

hal-04032984 , version 1 (16-03-2023)

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Seinde Toure, Marion Millot, Lucie Ory, Catherine Roullier, Zineb Khaldi, et al.. Access to Anti-Biofilm Compounds from Endolichenic Fungi Using a Bioguided Networking Screening. Journal of Fungi, 2022, 8 (10), pp.1012. ⟨10.3390/jof8101012⟩. ⟨hal-04032984⟩
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