Article Dans Une Revue Journal of Neuro-Ophthalmology Année : 2023

Retinal Thickness in Essential Tremor and Early Parkinson Disease: Exploring Diagnostic Insights

Giovanni Mostile
  • Fonction : Auteur
Clara Chisari
  • Fonction : Auteur
Cristina Rascunà
  • Fonction : Auteur
Roberta Terranova
  • Fonction : Auteur
Calogero Cicero
  • Fonction : Auteur
Loretta Giuliano
  • Fonction : Auteur
Giulia Donzuso
  • Fonction : Auteur
Giorgia Sciacca
  • Fonction : Auteur
Antonina Luca
  • Fonction : Auteur
Joseph Jankovic
  • Fonction : Auteur
Mario Zappia
  • Fonction : Auteur
Alessandra Nicoletti
  • Fonction : Auteur

Résumé

Background: Essential tremor (ET) represents a heterogeneous condition which may overlap with Parkinson disease (PD) even at early stages, by sharing some subtle clinical aspects. Longstanding ET demonstrated also higher risk of developing PD, especially with a Tremor-dominant (TD-PD) phenotype. Therefore, differential diagnosis between ET and early PD could be quite challenging. Optical coherence tomography (OCT) has been recognized as a reliable tool to assess the retina as a proxy of neurodegeneration. We aimed to explore the possible role of retinal assessment in differential diagnosis between ET and early PD. Methods: Macular layers and peripapillary retinal nerve fiber layer (RNFL) thickness among ET, early PD, and healthy controls (HCs) were assessed using OCT. Results: Forty-two eyes from 23 ET, 41 eyes from 21 early PD, and 33 eyes from 17 HCs were analyzed. Macular RNFL, ganglion cell layer, inner plexiform layer, and inner nuclear layer were thinner in PD as compared with ET and even more in HCs. Differences between ET and PD were more evident when considering the TD-PD subgroup, especially for RNFL. Among ET patients, thickness of the inner macular layers showed negative linear relationship with both age at onset and disease duration. Peripapillary temporal quadrant thinning was found in ET compared with HCs. Conclusions: Macular inner retina was thinner in patients with ET and early PD compared with HCs. These findings suggest that the retinal assessment may have a utility in the differential diagnosis between ET and PD.

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hal-04277264 , version 1 (04-04-2025)

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Claudio Terravecchia, Giovanni Mostile, Clara Chisari, Cristina Rascunà, Roberta Terranova, et al.. Retinal Thickness in Essential Tremor and Early Parkinson Disease: Exploring Diagnostic Insights. Journal of Neuro-Ophthalmology, 2023, ⟨10.1097/WNO.0000000000001959⟩. ⟨hal-04277264⟩
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