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Article Dans Une Revue Journal of Neurointerventional Surgery Année : 2023

WEB shape modifications: angiography–histopathology correlations in rabbits

Kevin Janot
Grégoire Boulouis
Géraud Forestier
Fouzi Bala
Jonathan Cortese
  • Fonction : Auteur
Zoltán Szatmáry
Sylvia M. Bardet
Maxime Baudouin
  • Fonction : Auteur
Marie-Laure Perrin
  • Fonction : Auteur
Jérémy Mounier
  • Fonction : Auteur
Claude Couquet
  • Fonction : Auteur
Catherine Yardin
  • Fonction : Auteur
Guillaume Segonds
  • Fonction : Auteur
Nicolas Dubois
  • Fonction : Auteur
Alexandra Martinez
  • Fonction : Auteur
Pierre-Louis Lesage
  • Fonction : Auteur
Yong-Hong Ding
  • Fonction : Auteur
Ramanathan Kadirvel
Daying Dai
Charbel Mounayer
  • Fonction : Auteur
Faraj Terro
  • Fonction : Auteur
Aymeric Rouchaud

Résumé

Background WEB Shape Modification (WSM) over time is frequent after aneurysm treatment. In this study, we explored the relationship between histopathological changes and angiographic evolution over time in experimental aneurysms in rabbits treated with the Woven EndoBridge (WEB) procedure. Methods Quantitative WSM was assessed using flat-panel computed tomography (FPCT) during follow-up by calculating height and width ratio (HR, WR), defined as the ratio between either measurement at an index time point and the measurement immediately after WEB implantation. The index time point varied from 1 day to 6 months. HR and WR were evaluated with angiographic and histopathological assessments of aneurysm healing. Results Final HR of devices varied from 0.30 to 1.02 and final WR varied from 0.62 to 1.59. Altogether, at least 5% of HR and WR variations were observed in 37/40 (92.5%) and 28/40 (70%) WEB devices, respectively, at the time of final assessment. There was no significant correlation between complete or incomplete occlusion groups and HR or WR (p=0.15 and p=0.43). Histopathological analysis revealed a significant association between WR and aneurysm healing and fibrosis 1 month following aneurysm treatment (both p<0.05). Conclusion Using longitudinal FPCT assessment, we observed that WSM affects both the height and width of the WEB device. No significant association was found between WSM and aneurysm occlusion status. Although presumably a multifactorial phenomenon, the histopathological analysis highlighted a significant association between width variations, aneurysm healing and fibrosis in the first month following aneurysm treatment.
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Dates et versions

hal-04412992 , version 1 (23-01-2024)

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Kevin Janot, Grégoire Boulouis, Géraud Forestier, Fouzi Bala, Jonathan Cortese, et al.. WEB shape modifications: angiography–histopathology correlations in rabbits. Journal of Neurointerventional Surgery, 2023, pp.jnis-2023-020193. ⟨10.1136/jnis-2023-020193⟩. ⟨hal-04412992⟩
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